Chemo-enzymatic amide synthesis
- researcher's name
- affiliation
- research field
-
Functional biochemistry
- keyword
-
background
● Amide compounds are useful material for food, cosmetics, pharmaceuticals.
● Chemical method requires multi-step reaction and generates a lot of waste.
● Enzymatic method limits the kinds of amide to synthesize.
● Chemical method requires multi-step reaction and generates a lot of waste.
● Enzymatic method limits the kinds of amide to synthesize.
summary
● A novel chemo-enzymatic reaction for the amide synthesis.
❍ Enzymatic reaction: activation of the carboxyl group of the substrate.
❍ Chemical reaction: nucleophilic substitution reaction to be various amides.
❍ Enzymatic reaction: activation of the carboxyl group of the substrate.
❍ Chemical reaction: nucleophilic substitution reaction to be various amides.
predominance
● Hybrid reaction produces amide compounds by one-pot reaction.
● Reaction proceeds under mild condition without special equipment.
● More amides can be synthesized compared to conventional method.
● Reaction proceeds under mild condition without special equipment.
● More amides can be synthesized compared to conventional method.
application/development
● Amide compounds for pharmaceuticals, prodrugs or chemicals.
● Dipeptides for functional food, supplements or materials.
● Fatty acid amides for surfactants.
● Dipeptides for functional food, supplements or materials.
● Fatty acid amides for surfactants.
same researcher's seeds
- The synthesis of high yield hydroxyaspartic acid and its use in antitumor drugs
- The emission of white light through enzyme hydration of 2-naphthoic acid
- A method of freely synthesizing hexapeptides from peptides
- Lipolytic microorganism and method for treating wastewater containing oil and fat using the same
posted:
2018/11/29