Chemo-enzymatic amide synthesis
2018-1123-06
- researcher's name
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about researcher KINO, Kuniki Professor
- affiliation
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Faculty of Science and Engineering School of Advanced Science and Engineering Department of Applied Chemistry
- research field
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Functional biochemistry
- keyword
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background
● Amide compounds are useful material for food, cosmetics, pharmaceuticals.
● Chemical method requires multi-step reaction and generates a lot of waste.
● Enzymatic method limits the kinds of amide to synthesize.
● Chemical method requires multi-step reaction and generates a lot of waste.
● Enzymatic method limits the kinds of amide to synthesize.
summary
● A novel chemo-enzymatic reaction for the amide synthesis.
❍ Enzymatic reaction: activation of the carboxyl group of the substrate.
❍ Chemical reaction: nucleophilic substitution reaction to be various amides.
❍ Enzymatic reaction: activation of the carboxyl group of the substrate.
❍ Chemical reaction: nucleophilic substitution reaction to be various amides.
predominance
● Hybrid reaction produces amide compounds by one-pot reaction.
● Reaction proceeds under mild condition without special equipment.
● More amides can be synthesized compared to conventional method.
● Reaction proceeds under mild condition without special equipment.
● More amides can be synthesized compared to conventional method.
application/development
● Amide compounds for pharmaceuticals, prodrugs or chemicals.
● Dipeptides for functional food, supplements or materials.
● Fatty acid amides for surfactants.
● Dipeptides for functional food, supplements or materials.
● Fatty acid amides for surfactants.
same researcher's seeds
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The emission of white light through enzyme hydration of 2-naphthoic acid
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A method of freely synthesizing hexapeptides from peptides
posted:
2018/11/29