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2019-1021-03
Life sciences
posted：2019/10/21
Probes for theranostics that target denatured collagen
KOIDE, Takaki Professor (Faculty of Science and Engineering)
● Remarkable improvement of affinity to target by cyclization of CMPs● Optimization of cyclic CMP (cCMP) design using structure-activity relationship
2018-0927-02
Life sciences
posted：2018/09/27
An artificial collagen-like material based on triple helix-forming peptides
KOIDE, Takaki Professor (Faculty of Science and Engineering)
● Polymerization of the collagen-like peptides by cross-linking via disulfide bonds● Functionalization by incorporating bioactive sequences derived from native collagen● Process into a transparent membrane by a drying/rehydration of the gel
2016-1024-06
Life sciences
posted：2016/10/24
Collagen-like Peptide Polymer with Gelating Property
KOIDE, Takaki Professor (Faculty of Science and Engineering)
● Disulfide-crosslinked polymer of triple-helical peptides (Fig. 1)● The material can be shaped into hydrogels and films etc. (Fig. 2).● Cell behaviors can be regulated by introducing signaling sequences (Fig. 3).● Cell behaviors can be regulated by altering the stiffness of t...
2015-1023-03
Life sciences
posted：2015/10/23
Novel antimicrobial peptides
KOIDE, Takaki Professor (Faculty of Science and Engineering)
Novel antimicrobial peptides which form triple-helical structure and contain Arg cluster in the N-terminal region and disulfide bonds in the C-terminal region.
2013-1022-01
Life sciences
posted：2013/10/25
コラーゲンを用いる新規DDS
KOIDE, Takaki Professor (Faculty of Science and Engineering)
・ステルス性と高尿排泄性を持つ今までに無い薬物担体・抗原性が低く安定
2011-0930-01
Life sciences
posted：2014/05/21
Drug development based on collagen
KOIDE, Takaki Professor (Faculty of Science and Engineering)
●Supramolecular materials having collagen-like triple-helical structure●Library of collagen-like triple-helical peptides (approximately 800 types)●Screening methods for collagen biological polymer bonding inhibitor compounds: (establishment of 384-well plate, high-throughput s...
