Novel antimicrobial peptides
- researcher's name
- affiliation
- research field
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Structural biochemistry,Drug development chemistry,Biomolecular chemistry
- keyword
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background
・ The development of new antibacterial agents was demanded because of increasing threat of multi-drug resistant bacteria.
・ Conventional antimicrobial peptides are readily degraded by proteases.
・ Conventional antimicrobial peptides are readily degraded by proteases.
summary
Novel antimicrobial peptides which form triple-helical structure and contain Arg cluster in the N-terminal region and disulfide bonds in the C-terminal region.
predominance
・ This peptide inhibited E. coli growth by a different mechanism from that of low molecular-weight antibiotics.
・ Remarkably stability in human serum.
・ More potent antimicrobial activity than magainin 2.
・ Low hemolytic and cytotoxic activities.
・ Remarkably stability in human serum.
・ More potent antimicrobial activity than magainin 2.
・ Low hemolytic and cytotoxic activities.
application/development
Orally administration for treating intestinal tract, intravenous administration for urinary tract infection,and antibacterial eye lotion, etc.
material
same researcher's seeds
posted:
2015/10/23