Development of magnetic nanoparticles for cancer care

2018-0927-05
researcher's name
affiliation
research field
Device related chemistry,Nanobioscience,Electronic materials/Electric materials
keyword

background

● Appropriate size for medical care, e.g. a suitable size for cellular uptake
● Appropriate magnetic properties, depending on size, for the treatment and diagnosis
● High biocompatibility and target specificity

summary

● Magnetite nanoparticles with the mean size tuned in the range of 10 to 40 nm
● High dispersibility of nanoparticles (modified with amine) in aqueous solution
● Use of cells containing nanoparticles in the treatment and diagnosis of cancer

predominance

● Control of magnetite properties by changing the particle size
● Effective incorporation with maintaining cell viability and cell function
● Utilization of  function and target specificity of immune cells

application/development

● Cancer immunotherapy (magnetically mediated immunotherapy)  
● Magnetic hyperthermia
● Magnetic resonance imaging

remarks

特許第5476620号「磁気微粒子包含細胞及びその製造方法」，発明者：逢坂哲彌，飯田広範，中西卓也，秋山靖人(静岡県立静岡がんセンター）
H. Iida, K. Takayanagi, T. Nakanishi, T. Osaka, J. Colloid Interface Sci., 314 (1), 274-280 (2007).
H. Iida, K. Takayanagi, T. Nakanishi, A. Kume, K. Muramatsu, Y. Kiyohara, Y. Akiyama, T. Osaka, Biotechnol. Bioeng., 101 (6), 1123-1128 (2008).

material

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posted: 2018/09/27