Microfiber Scaffold for Effective Induction of an Engineered Tissue by Introducing Conductive Polymer in the Core Layer

researcher's name
research field
Biomedical engineering/Biomaterial science and engineering,Polymer chemistry,Nanobioscience,Thin film/Surface and interfacial physical properties,Structural/Functional materials


● Engineered tissues fabricated from cells are useful for transplant ion therapy.
● Fast fabrication is useful for urgent therapy.
● Also valuable as the model tissues for drug assessment and pathogenic studies.


● Microfiber scaffold can align myoblasts to effectively form myotube (Fig. 1).
● Electric potential, promotes muscle tissue formation; highly conductive polymers (ex. PEDOT/PSS) are useful as the scaffold materials.
● We have developed the microfiber having PEDOT/PSS in the core layer (Fig. 2).


● Myotube formation is promoted without loading electric potential (Fig. 3). 
● Cell proliferation is also enhanced.
● Stably present in an aqueous culture medium in spite of water suspensibility of PEDOT/PSS by enclosing in the core layer.


● Medicinal industry: Regenerative tissues for transplantation therapy. 
● Drug industry:  Model tissues for drug assessment.
● Textile industry: Functional fiber and textile product.


  • Fig. 1. Scheme of the muscle tissue formation from myoblast via myotube.
  • Fig. 2. Microfiber having PEDOT/PSS in the core layer. (a) Scheme, (b) SEM image, scale bar 5 µm, (c) TEM image, scale bar 500 nm.
  • Fig. 3. (Center) Effective formation of myotubes by culturing on the microfiber with PEDOT/PSS in the core layer. (L) Sheath layer only, (R) Mixed materials fiber. Scale bar 200 µm.
posted: 2018/09/27