Microfiber Scaffold for Effective Induction of an Engineered Tissue by Introducing Conductive Polymer in the Core Layer

researcher's name
about researcher TAKEDA, Naoya Professor
Faculty of Science and Engineering School of Advanced Science and Engineering
research field
Biomedical engineering/Biomaterial science and engineering,Polymer chemistry,Nanobioscience,Thin film/Surface and interfacial physical properties,Structural/Functional materials


● Engineered tissues fabricated from cells are useful for transplant ion therapy.
● Fast fabrication is useful for urgent therapy.
● Also valuable as the model tissues for drug assessment and pathogenic studies.


● Microfiber scaffold can align myoblasts to effectively form myotube (Fig. 1).
● Electric potential, promotes muscle tissue formation; highly conductive polymers (ex. PEDOT/PSS) are useful as the scaffold materials.
● We have developed the microfiber having PEDOT/PSS in the core layer (Fig. 2).


● Myotube formation is promoted without loading electric potential (Fig. 3). 
● Cell proliferation is also enhanced.
● Stably present in an aqueous culture medium in spite of water suspensibility of PEDOT/PSS by enclosing in the core layer.


● Medicinal industry: Regenerative tissues for transplantation therapy. 
● Drug industry:  Model tissues for drug assessment.
● Textile industry: Functional fiber and textile product.


  • Fig. 1. Scheme of the muscle tissue formation from myoblast via myotube.
  • Fig. 2. Microfiber having PEDOT/PSS in the core layer. (a) Scheme, (b) SEM image, scale bar 5 µm, (c) TEM image, scale bar 500 nm.
  • Fig. 3. (Center) Effective formation of myotubes by culturing on the microfiber with PEDOT/PSS in the core layer. (L) Sheath layer only, (R) Mixed materials fiber. Scale bar 200 µm.

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posted: 2018/09/27