Drug for epigenomic disruption caused by hyperglycemia

background

Hyperglycemia caused by diabetic milieu is a risk factor for various diseases, including neuro-diseases,hypertension, stroke, immune diseases and cancer. Genome-wide epigenetic information (epigenome) is essential for proper gene function, including genome-stability, DNA repair, gene expression and splicing. Disruption of epigenome causes various types of chronic diseases.

summary

Does hyperglycemia cause a change of epigenome? A compound which prevents hyperglycemia-induced epigenomic aberration, could be a novel drug for diabetes associated with various diseases.

predominance

Suppression of epigenomic abnormality that hyperglycemia causes

application/development

Prevention and treatment for Hyper-glycemia related various diseases, including neuro-diseases,hypertension, stroke, immune diseases and cancer


material

collaborative researchers

ARAI, Daisuke Junior Researcher , 塩田 邦郎 教授 (東京大学大学院農学生命化学研究科 細胞生化学研究室)

posted: 2015/10/23