Neuronal differentiation inducer

background

・ Medicinal application of imidazole compounds,which have various bioactivities is focused.
・ Neuronal differentiation inducer could be a therapeutic drug for central nervous system diseases derived from the defects of neural stem cells.

summary

・ A series of novel ageladine A derivatives,which has a specific activity on the neuronal differentiation


predominance

・ Strong activity (effective at 10 nM)
・ Substructure-dependent function: 3c is an inhibitor of the neuronal differentiation

application/development

・ Lead compounds for neurodegenerative diseases
・ Tools for stem cell biology

material

  • In vitro neural differentiation method using mouse ES cell
  • A series of new derivatives derived from 2
  • Specific activity on the neuronal differentiation
  • Neuronal differentiation activity

collaborative researchers

    (理化学研究所生体機能合成化学研究室)

posted: 2015/10/23