Deficient DNA damage response and progeria
When DNA inside the nuclei of cells are damaged by radiation, ultraviolet light, chemicals, etc., it becomes fragmented or mutates. Normally, the damage is repaired by the DNA repair system, but aging is greatly accelerated when it fails to function properly due to a defect in the mechanism, sometimes leading to progeria. There are several thousand people around the world who suffer from Werner syndrome, a typical form of progeria, and many of them are Japanese
Through the functional analysis of multiple proteins involved in the copying, repair and recombination of DNA identified as being the genetic cause of progeria, we are carrying out research into the breakdown and accelerated aging of the mechanism that maintains genomic homeostasis through DNA damage stress.
Elucidating the state of progeria, and its diagnosis and treatment
The development of drugs, etc., that target illnesses associated with aging by making use of the mechanisms of progeria.
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