Amyloidß Detection System using CHRNA7 Fragments

2016-1024-08
researcher's name
affiliation
research field
Neurochemistry/Neuropharmacology
keyword

background

● Amyloid ß protein (Aß) is a main component of senile plaque.  
● It is important to detect Aß oligomer for AD prediction.
● CHRNA7 specifically binds to Aß.

summary

● We narrowed down the binding region of CHRNA7 to Aß.
● The methods to detect Aß using the purified GST-CHRNA7 fragments.
● We already confirmed the binding of Aß and the CHRNA7 fragments.

predominance

● The Aß species specifically bind CHRNA7 could be detected. 
● Specific and low-cost method compared to ELISA

application/development

● Developing biosensor to detect the Aß specifically binds to CHRNA7 
● Screening chemicals and drugs to inhibit the Aß-CHRNA7 binding

material

  • Fig. 1 Purification of GST-CHRNA7 fragments
  • Fig. 2 The new methods to detect Aß using the purified GST-CHRNA7
  • Fig. 3 Confirmation of the binding between Aß and the CHRNA7 fragments

same researcher's seeds

posted: 2016/10/24