Analytical systems of homologous recombination in the reconstituted chromatin
- researcher's name
- research field
Structural biochemistry,Functional biochemistry,Molecular biology
・ RAD51 and DMC1 are the central enzymes, which promote homologous pairing during homologous recombination.
・ RAD51 is expressed in both mitotic and meiotic cells, but DMC1 is only produced in meiotic cells.
The systems established in this study may provide a platform technology to develop new therapeutic ways for diseases which are caused by defective homologous recombination, such as cancer and infertility.
MACHIDA, Shinichi Junior Researcher (Faculty of Science and Engineering School of Advanced Science and Engineering) (retired) , KOBAYASHI, Wataru Assistant Professor (retired)