Development of Functional foods regulating circadian clock system

2015-1022-01

researcher's name: about researcher SHIBATA, Shigenobu Professor (retired)
affiliation: Faculty of Science and Engineering School of Advanced Science and Engineering
research field: Neurochemistry/Neuropharmacology
keyword

background

・ Circadian rhythm controls morning and evening
・ Rhythm deficit causes central and peripheral disease
・ Materials affect rhythm amplitude, phase and period

summary

・ Screening of food materials on rhythm in cells
・ Select from materials based on Amp, Phase, Period
・ Screening of food material for BF or Dinner on rhythm
・ Confirmed by clock gene mRNA in mice & human

predominance

・ Screening of functional food by view of Rhythm
・ Select food by Amp increase and phase advance
・ In vivo monitor of clock gene mRNA by mice & human
・ Development of BF or Dinner on Chrono-nutrition

application/development

・ Functional food for jet lag by shift work & flight
・ Functional food for Amp increase in old people
・ Functional food for BF or Dinner on Chrono-nutrition
・ Functional food for night food without obesity & arrhythmicity

material

Fig.1 Caffeine increased amplitude and lengthened circadian bioluminescence rhythm in PER2::LUC MEF cells.
Fig.2 Functional food A strongly inhibited absorption of Tg in mice Under 2 meals (breakfast, dinner) per day schedule.
Fig.3 Visualization of mouse peripheral clock in PER2::LUC mouse,and phase advance by restricted feeding during daytime.

posted: 2015/10/23