Drug for epigenomic disruption caused by hyperglycemia
2015-1022-04
- researcher's name
- affiliation
- research field
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Biomolecular chemistry
- keyword
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background
Hyperglycemia caused by diabetic milieu is a risk factor for various diseases, including neuro-diseases,hypertension, stroke, immune diseases and cancer. Genome-wide epigenetic information (epigenome) is essential for proper gene function, including genome-stability, DNA repair, gene expression and splicing. Disruption of epigenome causes various types of chronic diseases.
summary
Does hyperglycemia cause a change of epigenome? A compound which prevents hyperglycemia-induced epigenomic aberration, could be a novel drug for diabetes associated with various diseases.
predominance
Suppression of epigenomic abnormality that hyperglycemia causes
application/development
Prevention and treatment for Hyper-glycemia related various diseases, including neuro-diseases,hypertension, stroke, immune diseases and cancer
collaborative researchers
ARAI, Daisuke Part-time Lecturer (retired) , 塩田 邦郎 教授 (東京大学大学院農学生命化学研究科 細胞生化学研究室)
same researcher's seeds
posted:
2015/10/23
