Over 99% of the microorganisms in nature are difficult to culture, but among these unknown useful microorganisms may be included. Efficient culturing methods are essential for identifying through screening, microorganisms with properties such as virus resistance. 

New high-throughput in situ culturing tools and isolation and culturing techniques for useful microorganisms in the environment. It is possible to apply these methods to environments such as in underground and in water and obtain many new bacteria in one go. Because mass transfer through a hollow-fiber membrane is possible, we can perform isolation and culturing while still in the natural environment. (See figure)

For example, this can be used as a means of culturing, when screening microorganisms which can be used as agricultural chemicals, such as those having specific functions such as virus resistance and nitrogen degradation.

High culturing efficiency: over 10 times better than traditional plate culturing. High-throughput operation possible: can obtain in one culturing 10 – 100,000 lines of microorganisms.

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