Comparison of a murine model with humans using noninvasive measuring of biomagnetism, and its application in heart disease diagnosis

2011-0517-03
researcher's name
affiliation
research field
Power engineering/Power conversion/Electric machinery
keyword

background

The diagnoses of heart diseases other than those that are genetic often have to rely on electrocardiographs, making their early discovery difficult.

summary

We can provide a method of early heart disease detection that combines life science techniques with SQUID* measurements.
For example, we can create a murine model of myocardial infarction (a knockout mouse), and take magnetocardiographs using SQUID from birth until the onset of myocardial infarction, and then until it dies, to ascertain the changes that occur in the magnetocardiographs with the onset of myocardial infarction. Moreover, comparing them with the results of autopsies will allow us to make diagrams to draw correlations between the states of the disease and the magnetocardiographs.

* SQUID (superconducting quantum interference device): A high sensitivity magnetic sensor. It is able to measure weak magnetic fields (magnetoencephalographs and magnetocardiographs) generated by neurotransmissions (brain activity) or movement of the myocardium.

application/development

Comparing the magnetocardiographs of healthy people and mice allows prediction of the progress of heart diseases from the changes in people’s magnetocardiographs. Observing changes in the magnetocardiographs of murine models after administering drugs also enables evaluation of their effectiveness, and the changes may be correlated with the diagnoses of heart diseases and their treatments in people.

predominance

The strength of this research seed is based on our knowhow of SQUID systems for small animals and the building of measuring protocols.

purpose of providing seeds

Sponsord research, Collaboration research, Technical consultation

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posted: 2014/05/21