●  There is no prevention method of initiation and rupture of intracranial aneurysms.
●  Animal experiments for developing drugs fail to allow us to consider the effect of hemodynamics.
●  Little techniques as a drug-discovery assistance, which evaluate the effect of hemodynamics.

●  Establishment of a novel ex vivo technique of reproducing cerebral aneurysm.
●  Reproduce diseased state of the arteries from healthy by hemodynamic loading.
●  Reproduce degenerative change of arteries due to aberrant hemodynamics.

●  A capability of visualizing and analyzing the progressive state of disease in a time-lapse manner.
●  A capability of quantifying and controlling hemodynamics over animal experiments.

●  Pharmaceutical market of vascular diseases such as intracranial aneurysms.
●  Its prevalence reaches 5% of the people 50 years old or older.
●  No medical therapy developed, and only surgical procedures available.