表題番号：2018S-121
日付：2019/04/07
研究課題超音波誘導核化手法を用いたアミノ酸結晶の多形制御とその機構の解明
| 研究者所属（当時） | 資格 | 氏名 | |
|---|---|---|---|
| （代表者） | 理工学術院 先進理工学部 | 助手 | 池 勇樹 |
- 研究成果概要
Amino acids have been used in medical field and food field. However, design condition of production process of the amino acid crystal is limited because most of the amino acids show polymorphism. In this study, polymorph control of L-Arginine hydrochloride and L-phenylalanine by ultrasonic irradiation was confirmed, and the mechanism of selective crystallization was discussed in terms of local supersaturation at cavitation bubble. The cavitation bubble was observed by high speed camera and digital camera, and the concentration of bubbles was quantified by the camera images. The results suggest that higher output of ultrasonic irradiation would cause higher bubble concentration. In addition, experiment of crystallization using micro bubble generator was performed and the primary nucleation rate of each polymorph under the existence of micro bubble was observed. Subsequently, the ultrasonic-induced nucleation and the bubble-induced nucleation were analyzed using classical nucleation theory. The results suggested that the generation of bubbles would be one of the causes of polymorph control by ultrasonic-induced nucleation. These results were reported at international conference (Asian Crystallization Technology Symposium 2018).