表題番号:2014B-150 日付:2015/03/31
研究課題二重鎖切断の不完全情報から遺伝子混合の特性を推定する数学手法の研究
研究者所属(当時) 資格 氏名
(代表者) 商学学術院 大学院会計研究科 教授 豊泉 洋
研究成果概要
It is well-known that crossover formation events on a chromosome interfere with each other during meiosis, and this interference affects the distribution of genetic exchanges on a chromosome in sexual reproduction. However, due to the technical difficulties, it is unknown if meiotic double strand break (DSB) formation, the initiating event of meiotic recombination, shows interference. We discuss a method that employs probability theory of survival analysis in conjunction with: chromosome fragment distribution, detected by Southern blotting; and genome-wide DSB intensity maps, obtained by microarray analysis. We show that this method is a promising tool to analyse DSB interference.