Sins of anticancer drugs
2022-1020-05
- researcher's name
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about researcher ITO, Etsuro Professor
- affiliation
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Faculty of Education and Integrated Arts and Sciences School of Education
- keyword
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background
● Why can't cancer be cured? Is there anything wrong with anticancer drug treatment?
● Do small vesicles (exosomes) released from cancer cells contain factors that make cancer malignant?
● It is difficult to measure trace amounts of proteins in exosomes.
summary
● Whereas anyone can measure nucleic acids, what we really would like to know are the trace amounts of proteins that function in the body.
● Application of an ultrasensitive ELISA enables us to detect proteins responsible for malignant transformation.
predominance
● We can detect GRP78 contained in a small number of exosomes at an ultrasensitive level.
● High concentration of GRP78 in exosomes, which are secreted after anticancer drug administration, cause cancer cells to become malignant.
● The merits and demerits of anticancer drugs can be determined by detecting GRP78 in exosomes.
application/development
● This method is versatile due to its use as a drug screening method to determine drug efficacy.
● We can make a kit that is expected to be widely used.
same researcher's seeds
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Development of new diagnosis using ultrasensitive ELISA -
Ultrasensitive antigen test for COVID-19
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Activity change in the brain associated with pain relief
posted:
2022/10/24