In vitro NASH model with ballooned hepatocytes
2021-0921-09
- researcher's name
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about researcher SAKAGUCHI, Katsuhisa Part-time Lecturer (retired)
- affiliation
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Faculty of Science and Engineering Graduate School of Advanced Science and Engineering
- keyword
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background
● Since the prevalence of NASH is increasing year by year, drug development is urgently needed.
● It takes time to create an animal drug model.
summary
● When human fibroblasts and human hepatocytes are co-cultured, collected in sheets using UPCELL and
cultured in a high-glycolipid environment, ballooned hepatocytes are induced.
predominance
● Ballooned hepatocytes like human NASH
● Drug discovery model can be created in a short time.
● Screening is possible because it can be created with a small number
of cells.
application/development
● Model for drug discovery
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posted:
2021/10/08