Development of cosmetic products targeting cell endogenous activation

2019-1021-07
researcher's name
about researcher HARA, Taichi Professor
affiliation
Faculty of Human Sciences
keyword

background

● Reduced activity of protein quality system causes skin aging.
● Accumulation of abnormal mitochondria in cells produces reactive oxygen and accelerates skin damage.
● Reduction of cellular damage and abnormal proteins in the dermis are important issues for skin aging.

summary

● Degradation of abnormal proteins by enhancing autophagy.
● Elimination of damaged mitochondria by mitophagy reduces the source of active oxygen.
● Intrinsic protection from aging or environmental stress by increasing cellular stress response system

predominance

● We establish an evaluation system of autophagy and mitophagy in skin cells.
● We identify compounds affecting autophagy or mitophagy.
● We identify components that enhance the stress response system and verify the cytoprotective effect.

application/development

● Beauty, Skin-care, Cosmetic product
● Health food market
● Healthcare industry

material

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same researcher's seeds

  • Drug screening targeting intracellular accumulation of abnormal proteins
posted: 2019/10/21