Probes for theranostics that target denatured collagen

2019-1021-03
researcher's name
about researcher KOIDE, Takaki Professor
affiliation
Faculty of Science and Engineering
research field
Structural biochemistry,Drug development chemistry,Biomolecular chemistry
keyword

background

● Collagen mimetic peptides (CMPs) have the property of hybridizing with denatured collagen and are expected to be used as probes for  theranostics. However, the binding affinity of conventional CMPs is  low and the activity is lost by self-assembly. The CMPs thus requires denaturation just before use. Such pre-treatment causes technical  troubles and reduce reliability of the results.

summary

● Remarkable improvement of affinity to target by cyclization of CMPs
● Optimization of cyclic CMP (cCMP) design using structure-activity relationship

predominance

● Significant improvement of binding affinity to denatured collagen
● Free from troublesome pre-treatment of the peptide
● Controlable retention time in vivo

application/development

● Radiotheranostics and drug delivery targeting denatured collagen
● Prove for pathological diagnosis

material

  • 　
  • 　
  • 　
  • 　

same researcher's seeds

  • Drug development based on collagen
  • Novel antimicrobial peptides
  • Collagen-like Peptide Polymer with Gelating Property
  • An artificial collagen-like material based on triple helix-forming peptides
posted: 2019/10/21