Drug screening targeting intracellular accumulation of abnormal proteins

2018-0927-04
researcher's name
about researcher HARA, Taichi Professor
affiliation
Faculty of Human Sciences
keyword

background

● Intracellular accumulation of abnormal proteins is responsible for severe diseases (Fig. 1).   
● Intracellular accumulation of abnormal proteins is regulated by multistep protein quality control systems, leading the difficulty of drug discovery.

summary

● Elucidation of the molecular mechanisms for the intracellular accumulation of abnormal proteins (Fig. 2). 
● Development of screening technique targeting protein quality control systems.

predominance

● We have developed a technology for regulating protein quality control systems of abnormal proteins (Fig. 3). 
● We have established a drug screening system in which protein quality control systems are optimized to improve the hit rate.

application/development

● The medicine developer
● The food industry
● The bio-pharmaceutical industry

material

same researcher's seeds

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posted: 2018/09/27