An artificial collagen-like material based on triple helix-forming peptides
2018-0927-02
- researcher's name
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about researcher KOIDE, Takaki Professor
- affiliation
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Faculty of Science and Engineering
- research field
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Structural biochemistry,Drug development chemistry,Biomolecular chemistry
- keyword
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background
● Development of a totally artificial collagen surrogate as a biomaterial
● Requirements of biocompatibility, polymer properties and specific bio- functions
● Processability to medical devices
● Requirements of biocompatibility, polymer properties and specific bio- functions
● Processability to medical devices
summary
● Polymerization of the collagen-like peptides by cross-linking via disulfide bonds
● Functionalization by incorporating bioactive sequences derived from native collagen
● Process into a transparent membrane by a drying/rehydration of the gel
● Functionalization by incorporating bioactive sequences derived from native collagen
● Process into a transparent membrane by a drying/rehydration of the gel
predominance
● Safe (free from zoonotic pathogens) and steady supply
● Tunable functionalization
● Flexible processing
● Tunable functionalization
● Flexible processing
application/development
● As cell culture substrates
● As medical devices:
Ophthalmology : as an artificial cornea; as dressings for retinal
Injury other applications in dermatology, orthopedics, cardiovascular medicine, etc...
● As medical devices:
Ophthalmology : as an artificial cornea; as dressings for retinal
Injury other applications in dermatology, orthopedics, cardiovascular medicine, etc...
material
same researcher's seeds
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Drug development based on collagen -
Novel antimicrobial peptides
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Collagen-like Peptide Polymer with Gelating Property
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Probes for theranostics that target denatured collagen
posted:
2018/09/27