New Therapy of Precocious Puberty and Reproductive Dysfunction by Means of GnIH, a Novel Neurohormone
2016-1024-07
- researcher's name
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about researcher TSUTSUI, Kazuyoshi Professor (retired)
- affiliation
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Faculty of Education and Integrated Arts and Sciences School of Education
- keyword
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background
● The past has not been known only GnRH. Therefore, most of the central reproductive dysfunction were unidentified.
The effective therapy has not been developed.
summary
● Discovery of a novel neuro hormone(GnIH) (Fig.1)
● Elucidation of the molecular mechanism of the GnIH/GNIH action to control the reproductive function
- Central precocious puberty (CPP) that GnIH/GNIH functional decline leads (Fig.2)
- Central reproductive dysfunction (CRD) that hyperfunction of GnIH/GNIH leads (Fig.3)
predominance
● Discovery of Gonadotropin-inhibitory hormone (GnIH)
● Identification of the new reproductive control mechanism
● Identification of the new reproductive control mechanism
application/development
● Development
- GNIH agonists (New medicine for CPP)
- GNIH antagonist (New medicine for CRD)
- New diagnostic test (variant screening of GNIH gene and the receptor)
- GNIH agonists (New medicine for CPP)
- GNIH antagonist (New medicine for CRD)
- New diagnostic test (variant screening of GNIH gene and the receptor)
material
posted:
2016/10/24