Collagen-like Peptide Polymer with Gelating Property

2016-1024-06
researcher's name
about researcher KOIDE, Takaki Professor
affiliation
Faculty of Science and Engineering
research field
Structural biochemistry,Drug development chemistry,Biomolecular chemistry
keyword

background

● Needs of prion- and allergen-free collagen surrogates
● Natural collagen is multifunctional protein whose functions are indivisible.
● Preparation of recombinant collagen is still difficult


summary

● Disulfide-crosslinked polymer of triple-helical peptides (Fig. 1)
● The material can be shaped into hydrogels and films etc. (Fig. 2).
● Cell behaviors can be regulated by introducing signaling sequences (Fig. 3).
● Cell behaviors can be regulated by altering the stiffness of the gel (Fig. 4).


predominance

● Enable to parameterize the collagen functions
● Free from pathogens or allergens
● Compatible with recombinantly expressed peptides
● Flexible in molecular design for functionalization

application/development

● Substrates for cell culture including stem cells
● Materials for medical use ex. Wound dressing, artificial cornea

material

  • Fig.1 Polymerization of synthetic triple-helical peptides
  • Fig.2 Hydrogel (left), dried film (center),and rehydrated film (right)
  • Fig.3 Sequence-dependent signal inputs that regulate cell behaviors
  • Fig.4 Cell attachment and aggregating property can be regulated by altering gel stiffness.

same researcher's seeds

  • Drug development based on collagen
  • Novel antimicrobial peptides
  • An artificial collagen-like material based on triple helix-forming peptides
  • Probes for theranostics that target denatured collagen
posted: 2016/10/24