On-Chip Quasi-in vivo Assay Technology for Predictive Drug Discovery and Diagnostics
2016-1024-02
- researcher's name
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安田 賢二 教授
- affiliation
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理工学術院 先進理工学部
- keyword
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background
● Development of human iPS cells has enabled us to move to the quasi-in vivo era for precise predictive drug discovery and diagnostics beyond conventional in vitro technologies
summary
● We have developed an on-chip quasi-in vivo technology consisting of, (1) non-invasive cell sorting, (2) 3-D cell network formation, (3) non-destructive single cell dynamics measurement.
predominance
● The quasi-in vivo system can measure cell-to-cell conduction, community effect of cells which are keys to avoid false negative/positive judgement and cannot be measured in the conventional in vitro assays.
application/development
● Functional on-chip cell sorter system for regenerative medicine
● Predictive cardiotoxicity assay, Neuronal network (LTP) assay
● Predictive cardiotoxicity assay, Neuronal network (LTP) assay
material
posted:
2016/10/24