On-Chip Quasi-in vivo Assay Technology for Predictive Drug Discovery and Diagnostics

2016-1024-02
researcher's name
安田 賢二 教授
affiliation
理工学術院　先進理工学部
keyword

background

● Development of  human iPS cells has enabled us to move to the quasi-in vivo era for precise predictive drug discovery and diagnostics beyond conventional in vitro technologies

summary

● We have developed an on-chip quasi-in vivo technology consisting of, (1) non-invasive cell sorting, (2) 3-D cell network formation, (3) non-destructive single cell dynamics measurement.

predominance

● The quasi-in vivo system can measure cell-to-cell conduction, community effect of cells which are keys to avoid false negative/positive judgement and cannot be measured in the conventional in vitro assays.

application/development

● Functional on-chip cell sorter system for regenerative medicine
● Predictive cardiotoxicity assay, Neuronal network (LTP) assay 

material

  • Fig.1 Strategy of on-chip quasi-in vivo assay technology.
  • Fig.2 3-D cell network microfabrication technology and three non-invasive single cell analysis technologies (external field potential of cell, force generation, and extracts) for quasi-in vivo analysis assay.
posted: 2016/10/24