Visualization of the brain’s response to stimuli (smell) in a murine model using noninvasive measuring of biomagnetism

researcher's name
about researcher ISHIYAMA, Atsushi Professor
Faculty of Science and Engineering School of Advanced Science and Engineering
research field
Power engineering/Power conversion/Electric machinery


Intracerebral nervous activity in people can be observed macroscopically using MRIs and electroencephalographs, but it is difficult to obtain microscopic information including that of the process of neurtransmission.


The SQUID (superconducting quantum interference device), which is a high sensitivity magnetic sensor, is able to measure subtle magnetic fields (magnetoencephalographs) created by nervous activity, and it is not hindered by the skull. This allows the accurate and individual tracking of nervous activity. For example, comparing the magnetoencephalographs of odorant receptor deficient murine models that do not respond to odorant stimuli (knockout mice), with those of normal mice, allows accurate visualization of cerebral nerve activities in response to chemical odorant stimuli.


In terms of its applications, we believe that it will allow the elucidation of differences in cerebral nerve activities (differences depending on whether the stimuli are pleasant or unpleasant, and the processes by which the memory is stored or recalled) by changing the type of smell or other subtle conditions


The strength of this research seed is based on our knowhow of SQUID systems for small animals and the building of measuring protocols, so the technology can be used on a variety of organisms, stimuli, etc., in accordance with the requirements.

purpose of providing seeds

Sponsord research, Collaboration research, Technical consultation

same researcher's seeds

  • Investigation of prenatal care through noninvasive diagnosis and analysis
  • Comparison of a murine model with humans using noninvasive measuring of biomagnetism, and its application in heart disease diagnosis
  • Comparison of a murine model with humans using noninvasive measuring of biomagnetism, and its application in brain disease diagnosis
posted: 2014/05/21