The synthesis of high yield hydroxyaspartic acid and its use in antitumor drugs

researcher's name
about researcher KINO, Kuniki Professor
Faculty of Science and Engineering School of Advanced Science and Engineering Department of Applied Chemistry
research field
Functional biochemistry


The method of organically synthesizing hydroxyaspartic acid has been established, but there are many processes involved making it complicated.


In this research seed we succeeded in synthesizing hydroxyaspartic acid, with 100% yield, through site-specific addition of hydroxyl groups to aspartic acid in few steps, by making use of the biological reactions of enzymes.


Other than aspartic acid, we also have numerous enzymes with specific properties extracted from microorganisms, and methods of modifying enzymes to realize specific properties.
This allows us to manipulate hydration reactions using enzymes in a variety of amino acids including valine, leucine and methionine.


Great expectations are held for the use of hydroxyaspartic in external preparations for skin, neurotransmitter inhibitors and antitumor drugs, so our method involving few steps with high yield is advantageous at this developmental stage.

purpose of providing seeds

Sponsord research, Collaboration research, Technical consultation

same researcher's seeds

  • The emission of white light through enzyme hydration of 2-naphthoic acid
  • A method of freely synthesizing hexapeptides from peptides
  • Chemo-enzymatic amide synthesis
  • Lipolytic microorganism and method for treating wastewater containing oil and fat using the same
posted: 2014/05/21