Microfiber Scaffold for Effective Induction of an Engineered Tissue by Introducing Conductive Polymer in the Core Layer
2018-0927-06
- researcher's name
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about researcher TAKEDA, Naoya Professor
- affiliation
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Faculty of Science and Engineering School of Advanced Science and Engineering
- research field
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Biomedical engineering/Biomaterial science and engineering,Polymer chemistry,Nanobioscience,Thin film/Surface and interfacial physical properties,Structural/Functional materials
- keyword
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background
● Engineered tissues fabricated from cells are useful for transplant ion therapy.
● Fast fabrication is useful for urgent therapy.
● Also valuable as the model tissues for drug assessment and pathogenic studies.
● Fast fabrication is useful for urgent therapy.
● Also valuable as the model tissues for drug assessment and pathogenic studies.
summary
● Microfiber scaffold can align myoblasts to effectively form myotube (Fig. 1).
● Electric potential, promotes muscle tissue formation; highly conductive polymers (ex. PEDOT/PSS) are useful as the scaffold materials.
● We have developed the microfiber having PEDOT/PSS in the core layer (Fig. 2).
● Electric potential, promotes muscle tissue formation; highly conductive polymers (ex. PEDOT/PSS) are useful as the scaffold materials.
● We have developed the microfiber having PEDOT/PSS in the core layer (Fig. 2).
predominance
● Myotube formation is promoted without loading electric potential (Fig. 3).
● Cell proliferation is also enhanced.
● Stably present in an aqueous culture medium in spite of water suspensibility of PEDOT/PSS by enclosing in the core layer.
● Cell proliferation is also enhanced.
● Stably present in an aqueous culture medium in spite of water suspensibility of PEDOT/PSS by enclosing in the core layer.
application/development
● Medicinal industry: Regenerative tissues for transplantation therapy.
● Drug industry: Model tissues for drug assessment.
● Textile industry: Functional fiber and textile product.
● Drug industry: Model tissues for drug assessment.
● Textile industry: Functional fiber and textile product.
material
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Fig. 1. Scheme of the muscle tissue formation from myoblast via myotube.
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Fig. 2. Microfiber having PEDOT/PSS in the core layer. (a) Scheme, (b) SEM image, scale bar 5 µm, (c) TEM image, scale bar 500 nm.
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Fig. 3. (Center) Effective formation of myotubes by culturing on the microfiber with PEDOT/PSS in the core layer. (L) Sheath layer only, (R) Mixed materials fiber. Scale bar 200 µm.
same researcher's seeds
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Self-driven Perfusion Culture System Using the Paper-based Double-layered Scaffold -
Cellulose Nanofibers for Application in Regenerative Medicine ～ Fabrication of Engineered Tissues by Cell Culture in Thixotropic Gel ～
posted:
2018/09/27