Drug screening targeting intracellular accumulation of abnormal proteins
2018-0927-04
- researcher's name
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about researcher HARA, Taichi Professor
- affiliation
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Faculty of Human Sciences School of Human Sciences
- keyword
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background
● Intracellular accumulation of abnormal proteins is responsible for severe diseases (Fig. 1).
● Intracellular accumulation of abnormal proteins is regulated by multistep protein quality control systems, leading the difficulty of drug discovery.
● Intracellular accumulation of abnormal proteins is regulated by multistep protein quality control systems, leading the difficulty of drug discovery.
summary
● Elucidation of the molecular mechanisms for the intracellular accumulation of abnormal proteins (Fig. 2).
● Development of screening technique targeting protein quality control systems.
● Development of screening technique targeting protein quality control systems.
predominance
● We have developed a technology for regulating protein quality control systems of abnormal proteins (Fig. 3).
● We have established a drug screening system in which protein quality control systems are optimized to improve the hit rate.
● We have established a drug screening system in which protein quality control systems are optimized to improve the hit rate.
application/development
● The medicine developer
● The food industry
● The bio-pharmaceutical industry
● The food industry
● The bio-pharmaceutical industry
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posted:
2018/09/27