Novel antimicrobial peptides

2015-1023-03
researcher's name
affiliation
research field
Structural biochemistry,Drug development chemistry,Biomolecular chemistry
keyword

background

・ The development of new antibacterial agents was demanded because of increasing threat of multi-drug resistant bacteria.
・ Conventional antimicrobial peptides are readily degraded by proteases.

summary

Novel antimicrobial peptides which form triple-helical structure and contain Arg cluster in the N-terminal region and disulfide bonds in the C-terminal region.

predominance

・ This peptide inhibited E. coli growth by a different mechanism from that of low molecular-weight antibiotics.
・ Remarkably stability in human serum.
・ More potent antimicrobial activity than magainin 2.
・ Low hemolytic and cytotoxic activities.

application/development

Orally administration for treating intestinal tract, intravenous administration for urinary tract infection,and antibacterial eye lotion, etc.

material

  • Fig 1. Selection of antimicrobial peptides from collagen-like peptide library.
  • Fig 2. Antimicrobial activity of peptides against E. coli
  • Table 1. Relationship between peptide structure and antimicrobial activity
  • Fig 3. (left) Hemolysis of human red blood cells. (right) Cytotoxicity to HDF cells.

same researcher's seeds

posted: 2015/10/23